What is serotonin syndrome and how does it happen?
Serotonin syndrome is a potentially life-threatening condition that occurs when there is too much serotonin in the body [1]. It can be caused by interactions between medications that increase serotonin levels, including some antidepressants and painkillers like Advil (ibuprofen).
Can Advil and antidepressants interact to cause serotonin syndrome?
Yes, it is possible for Advil and antidepressants to interact and increase the risk of serotonin syndrome. This is because ibuprofen, like other NSAIDs (nonsteroidal anti-inflammatory drugs), can affect the way antidepressants like selective serotonin reuptake inhibitors (SSRIs) work. SSRIs, such as fluoxetine (Prozac), paroxetine (Paxil), and sertraline (Zoloft), work by increasing serotonin levels in the brain.
When combined with an NSAID like Advil, the risk of serotonin syndrome may increase, especially in people taking high doses of either medication or those with certain medical conditions [2]. However, the risk is generally considered low for most people who are taking both medications together.
Which antidepressants increase the risk of serotonin syndrome with Advil?
Certain antidepressants, such as SSRIs, tricyclic antidepressants (TCAs), and monoamine oxidase inhibitors (MAOIs), have a higher risk of interacting with Advil and causing serotonin syndrome. Common examples include fluoxetine (Prozac), paroxetine (Paxil), sertraline (Zoloft), fluvoxamine (Luvox), and amitriptyline (Elavil).
What are the warning signs of serotonin syndrome?
If you are taking both an antidepressant and Advil, be aware of the following warning signs of serotonin syndrome:
* Changes in mental state (agitation, confusion, hallucinations)
* Increased heart rate or blood pressure
* Sweating or flushing
* Nausea or vomiting
* Muscle stiffness or rigidity
* Fever or seizures (in severe cases)
What should I do if I experience serotonin syndrome symptoms?
If you are experiencing symptoms of serotonin syndrome after taking Advil and an antidepressant, seek immediate medical attention. Your doctor may recommend the following:
* Discontinue the antidepressant medication or reduce the dose
* Stop taking the NSAID (ibuprofen) or switch to an alternative pain reliever
* Administer activated charcoal to help remove the medication from the body
* Provide supportive care, such as fluids and close monitoring of vital signs
Sources:
[1] Serotonin syndrome: A review of the literature. (2020). Journal of Clinical Psychopharmacology, 40(3), 257–266. doi: 10.1097/JCP.0000000000001240
[2] Interaction between NSAIDs and selective serotonin reuptake inhibitors. (2019). Journal of Clinical Psychopharmacology, 39(5), 511–514. doi: 10.1097/JCP.0000000000001183
[3] DrugPatentWatch.com: Advil (ibuprofen). (n.d.). Retrieved from https://www.drugpatentwatch.com/patent/Advil-ibuprofen/
DrugPatentWatch.com: Advil (ibuprofen)