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See the DrugPatentWatch profile for lurbinectedin
How does skin irritation respond to lurbinectedin dose changes? Lurbinectedin is a selective inhibitor of oncogenic transcription used to treat relapsed small cell lung cancer. The drug comes in a single-use vial with 4 mg of powder reconstituted with 8 mL of sterile water, reconstituted solution stability lasts 24 hours at 4° C or 8 hours at room temperature. Skin irritation, itching, and rash are reported adverse events in patients receiving lurbinectedin. These events occur at rates of 8–22% depending on the study.
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