How does skin irritation respond to lurbinectedin dose changes?

How does skin irritation respond to lurbinectedin dose changes?

Lurbinectedin is a selective inhibitor of oncogenic transcription used to treat relapsed small cell lung cancer. The drug comes in a single-use vial with 4 mg of powder reconstituted with 8 mL of sterile water, reconstituted solution stability lasts 24 hours at 4° C or 8 hours at room temperature.

Skin irritation, itching, and rash are reported adverse events in patients receiving lurbinectedin. These events occur at rates of 8–22% depending on the study.