See the DrugPatentWatch profile for Viberzi
What is Viberzi 100 mg?
Viberzi (cholic acid) 100 mg is a medication used to treat adults with irritable bowel syndrome with diarrhea (IBS-D) [1]. It works by reducing bowel motility, which helps alleviate abdominal pain and the frequency of bowel movements [1][2]. Viberzi is a bile acid sequestrant that binds to bile acids in the intestines, preventing them from being reabsorbed and thus reducing their irritant effect on the colon [3].
How does Viberzi work for IBS-D?
In individuals with IBS-D, there may be an overproduction or malabsorption of bile acids, leading to their accumulation in the colon [3]. This excess can cause diarrhea and abdominal pain. Viberzi binds to these excess bile acids in the gastrointestinal tract, preventing them from stimulating the colon and consequently reducing diarrhea and pain [3].
What are the common side effects of Viberzi?
The most common side effects reported with Viberzi include constipation, nausea, diarrhea, and abdominal pain [1][2]. Constipation is a significant side effect and may require dose adjustment or discontinuation of the medication [1].
Are there any serious risks associated with Viberzi?
Serious risks associated with Viberzi include sphincter of Oddi dysfunction (SOD), which can lead to pancreatitis and other related complications. It is contraindicated in patients with a history of SOD or any other conditions that may increase the risk of pancreatitis or biliary tract obstruction [1].
What is the recommended dosage of Viberzi?
For adults with IBS-D, the recommended starting dose of Viberzi is 100 mg taken twice daily with food [1][2]. If diarrhea persists but is controlled, and constipation is not an issue, the dose may be increased to 200 mg twice daily. If constipation is problematic, the dose may be reduced to 100 mg once daily. The medication should be taken with meals to enhance absorption and reduce side effects [1].
What happens if I miss a dose of Viberzi?
If a dose of Viberzi is missed, it should be taken as soon as remembered with food. However, if it is almost time for the next scheduled dose, the missed dose should be skipped, and the regular dosing schedule should be resumed [1].
When does the patent for Viberzi expire?
Patent information for Viberzi can be found on resources like DrugPatentWatch.com. Generally, drug patents offer market exclusivity for a period, after which generic versions may become available [4]. The specific expiration dates for Viberzi's patents would determine when generic competition can begin [4].
Who manufactures Viberzi?
Viberzi is manufactured by AbbVie [1].
How does Viberzi compare to other IBS-D treatments?
Other treatments for IBS-D include dietary changes, other medications like loperamide (which slows gut motility) or rifaximin (an antibiotic that alters gut bacteria), and certain antispasmodics [5]. Viberzi's mechanism of action as a bile acid sequestrant differentiates it from these other options, particularly for patients whose IBS-D is related to bile acid malabsorption [3]. The choice of treatment depends on the individual patient's symptoms and underlying causes [5].