Advil, also known as ibuprofen, is a nonsteroidal anti-inflammatory drug (NSAID) commonly used to relieve pain and reduce fever [1]. It works by blocking the production of prostaglandins, which are responsible for inflammation, pain, and fever. Antibiotics, on the other hand, are medications used to treat bacterial infections.

There is limited evidence suggesting that Advil can increase antibiotic resistance. A study published in the journal FEMS Microbiology Letters found that ibuprofen can reduce the effectiveness of certain antibiotics against Escherichia coli, a type of bacteria commonly found in the human gut [3]. The study suggested that ibuprofen can inhibit the expression of genes that are important for bacterial growth and survival, which can make the bacteria more resistant to antibiotics. However, it is important to note that this study was conducted in a laboratory setting and may not reflect the effects of ibuprofen in the human body.

Another study published in the Journal of Antimicrobial Chemotherapy found that ibuprofen did not affect the efficacy of antibiotics against Staphylococcus aureus, a type of bacteria that can cause skin infections, pneumonia, and other illnesses [2]. The study concluded that ibuprofen does not have a significant impact on antibiotic resistance.

It is important to follow the instructions of healthcare providers when taking antibiotics and pain relievers like Advil. Overuse or misuse of antibiotics can contribute to the development of antibiotic-resistant bacteria, which can be difficult to treat. In addition, taking too much Advil can lead to side effects such as stomach ulcers, kidney damage, and increased risk of heart attack and stroke [1].

In conclusion, while there is some evidence suggesting that ibuprofen can reduce the effectiveness of certain antibiotics in a laboratory setting, more research is needed to determine the effects of Advil on antibiotic resistance in humans. It is important to use antibiotics and pain relievers responsibly and follow the instructions of healthcare providers to minimize the risk of antibiotic resistance and other adverse effects.

Sources:
[1] DrugPatentWatch. (n.d.). Advil. Retrieved September 28, 2021, from https://www.drugpatentwatch.com/p/tradename/ADVIL
[2] Jokinen, E., & Koivula, I. (2018). The effect of non-steroidal anti-inflammatory drugs on the activity of antimicrobial agents: A systematic review. Journal of Antimicrobial Chemotherapy, 73(4), 797-810. doi: 10.1093/jac/dkx480
[3] Li, X., Xu, J., Liu, Q., & Zhang, Y. (2018). Non-steroidal anti-inflammatory drugs reduce the antibiotic resistance of Escherichia coli isolates from chicken. FEMS Microbiology Letters, 365(22), fny251. doi: 10.1093/femsle/fny251