| Active ingredient |
Ammonium lactate (12 % w/v) |
| Drug class |
Salicylic acid‑like keratolytic (lactic acid derivative) |
| Common brand names |
Amlo, Amlo‑Lact, Amlo‑Lac, other generic OTC formulations |
| Typical strengths |
12 % lotion, 12 % cream, 12 % gel |
| Formulation |
Emulsion of ammonium lactate in a moisturizing base (water, glycerin, emulsifiers, preservatives). |
| Indications |
1. Keratoses (keratinous skin disorders) – such as keratosis pilaris, warts, calluses, corns, plantar warts, and mild actinic keratoses.
2. Psoriasis – used as a topical adjunct for localized plaques.
3. Xerosis (dry skin) – can be used to soften and moisturize rough skin. |
| How it works |
• Keratolytic action – ammonium lactate breaks down the protein bonds (desmosomes) between keratinocytes, promoting desquamation of the stratum corneum.
• Humectant – lactate draws water into the skin, improving hydration and reducing fissuring. |
| Typical dosing |
• Application: Apply a thin layer to the affected area 1–2 × daily (morning and/or evening).
• Duration: Often 2–4 weeks; continue until the skin improves or as directed by a healthcare provider.
• Do not leave on broken or infected skin. |
| Common side effects |
• Mild stinging, burning or itching upon application (usually resolves within minutes).
• Redness or mild irritation if over‑used.
• Rarely, contact dermatitis in sensitive individuals. |
| Precautions & Contraindications |
• Pregnancy/Breastfeeding – generally considered safe (category C), but consult a provider.
• Open wounds or ulcers – avoid application.
• Use with caution on thin skin (eyelids, genital skin).
• Not for ingestion – external use only. |
| Drug interactions |
• No systemic interactions since it is topical.
• If used with other keratolytic agents (e.g., salicylic acid, tretinoin), watch for increased irritation. |
| Storage |
Keep in a cool, dry place; keep container tightly closed. Avoid freezing. |
| Patient counseling points |
1. Apply as directed – don’t over‑apply; a thin film is sufficient.
2. Wash hands after application to avoid eye contact.
3. If irritation persists (severe redness, blistering) stop use and seek medical advice.
4. For warts or skin lesions – use only for the specified duration; prolonged use may be ineffective or harmful.
5. Avoid mixing with high‑potency corticosteroids unless advised by a provider. |
| When to see a healthcare professional |
• No improvement after 4–6 weeks of consistent use.
• Persistent or worsening lesions.
• Signs of infection (pus, increased redness, fever). |