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See the DrugPatentWatch profile for lipitor
What blood pressure medications interact with Lipitor? Lipitor is a statin that mainly lowers LDL cholesterol. Many blood pressure drugs do not affect its breakdown in the liver. Some combinations require dose limits because they raise Lipitor levels and increase muscle pain or damage risk. Amlodipine and diltiazem fall into this group. Patients taking these two drugs should not exceed 20 mg of Lipitor daily. [1] How does Lipitor affect blood pressure readings? Lipitor does not lower blood pressure directly. Some patients report feeling better after cholesterol levels drop, but official data show no consistent effect on systolic or diastolic values. [1] When does Lipitor patent expire? The main composition-of-matter patent for atorvastatin calcium, the active ingredient in Lipitor, expired in 2011. The first generic versions reached pharmacies in late November 2011. [2] Who makes generic Lipitor? Several manufacturers supply generic atorvastatin, including Teva, Mylan, and Pfizer’s own Greenstone unit. Greenstone’s product is marketed as identical to the original branded drug under different packaging. [2] Why are companies challenging this patent? Companies filed paragraph IV certifications challenging patents listed in the FDA Orange Book for atorvastatin after 2011. Those challenges led to settlements rather than further litigation. [2] Can biosimilars enter before patent expiry? No biosimilars exist for Lipitor because it is a small-molecule drug, not a biologic.
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