Does Lyrica (pregabalin) lower blood pressure in people?
Lyrica (pregabalin) is not an established blood-pressure-lowering medicine. It can cause side effects that affect circulation, and some people may see blood pressure drop, but that is typically framed as a possible adverse effect rather than a predictable or targeted effect.
What blood-pressure changes are linked to Lyrica?
Some patients taking pregabalin report dizziness or lightheadedness, which can happen with lower blood pressure (for example, orthostatic hypotension—blood pressure dropping when you stand up). This is usually monitored and managed as a safety concern, especially in people who are prone to low blood pressure or dehydration.
If you are tracking your numbers, pay attention to patterns when changing positions (lying down to standing) rather than only readings at rest.
Who is more likely to feel low blood pressure on Lyrica?
Risk is higher if you already tend to run low or if you have other factors that can worsen lightheadedness, such as:
- Taking blood-pressure–lowering medicines
- Dehydration or low fluid intake
- Older age
- Other medicines that can cause dizziness/sedation
If you’re combining Lyrica with antihypertensives, it’s reasonable to monitor blood pressure when starting or changing doses.
Should you stop Lyrica if your blood pressure drops?
Do not stop Lyrica on your own. If you have symptomatic low blood pressure (fainting, severe dizziness, chest pain, or dangerously low readings), contact your prescriber promptly. Your clinician may adjust the dose, timing, or review interacting medications.
What to do if you think Lyrica is affecting your blood pressure
- Take readings while seated and after standing (if your clinician recommends it), and note symptoms.
- Report the pattern and timing to your prescriber, especially soon after dose changes.
- Ask whether any other medicines or conditions could be contributing (diuretics, other sedatives, dehydration, etc.).