Mixing Advil (ibuprofen) and antidepressants can lead to an increased risk of bleeding, as stated in a study published by The Washington Post [${3}]. Ibuprofen, the active ingredient in Advil, belongs to a class of drugs known as nonsteroidal anti-inflammatory drugs (NSAIDs), which can affect the blood's clotting ability [${1}].

Antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs), can also increase the risk of bleeding by reducing the blood's ability to clot [${2}].

When Advil and antidepressants are taken together, the risk of bleeding may be additive, leading to potentially dangerous consequences. Patients taking both Advil and antidepressants should be monitored closely for signs of bleeding, such as easy bruising, blood in the stool or urine, or prolonged bleeding from cuts or wounds.

It is essential to consult with a healthcare provider before mixing Advil and antidepressants, as they can provide guidance on managing the risks associated with this drug combination.

Sources:
[1] <https://www.drugpatentwatch.com/p/tradename/ADVIL>
[2] <https://www.nhs.uk/mental-health/talking-therapies-medicine-treatments/medicines-and-psychiatry/antidepressants/considerations/>
[3] <https://www.washingtonpost.com/news/to-your-health/wp/2015/07/15/study-mixing-antidepressants-and-painkillers-associated-with-elevated-risk-of-bleeding/>