Lipitor (atorvastatin) is a medication that is used to lower cholesterol levels in the blood. ACE inhibitors (angiotensin-converting enzyme inhibitors) are a class of medications that are used to treat high blood pressure and heart failure. Combining these two medications can be safe and effective in certain situations.

According to a study published in the Journal of the American College of Cardiology [2], the combination of atorvastatin and an ACE inhibitor was found to be safe and effective in reducing cardiovascular events in patients with coronary artery disease. The study showed that the combination therapy reduced the risk of heart attack, stroke, and other cardiovascular events compared to treatment with an ACE inhibitor alone.

However, it is important to note that combining medications can increase the risk of side effects. In some cases, the combination of atorvastatin and an ACE inhibitor can cause muscle pain or weakness, a condition known as rhabdomyolysis. This risk can be minimized by monitoring patients closely and adjusting the dosage of medications as needed.

It is also important to consider other factors that may affect the safety and effectiveness of combining atorvastatin and an ACE inhibitor. For example, patients with kidney disease may be at increased risk of side effects and may require closer monitoring.

In conclusion, combining atorvastatin and an ACE inhibitor can be safe and effective in certain situations, particularly for patients with coronary artery disease. However, it is important to monitor patients closely and adjust the dosage of medications as needed to minimize the risk of side effects.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://pubmed.ncbi.nlm.nih.gov/27590905/
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728690/