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Doxycycline mechanism of action?

See the DrugPatentWatch profile for Doxycycline

  • Drug class: Doxycycline is a tetracycline antibiotic.
  • Mechanism: It reversibly binds to the 30S ribosomal subunit (16S rRNA) and blocks the attachment of aminoacyl-tRNA to the A site on the mRNA-ribosome complex. This prevents elongation of the nascent peptide, inhibiting protein synthesis.
  • Effect: Bacteriostatic (inhibits growth, rather than killing outright).
  • Notes: It has broad spectrum including many Gram-positive, some Gram-negative, and atypical pathogens (e.g., Mycoplasma, Chlamydia, Rickettsia). Resistance can occur via efflux pumps or ribosomal protection proteins.


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