Buspirone is an anxiolytic medication. Its primary active ingredient is buspirone hydrochloride [1].
What else is in a buspirone tablet?
Beyond the active ingredient, buspirone hydrochloride, tablets also contain inactive ingredients. These excipients are used to form the tablet, aid in its dissolution, and improve stability. Common inactive ingredients found in buspirone tablets include:
* Microcrystalline cellulose [2]
* Lactose monohydrate [2]
* Magnesium stearate [2]
* Sodium starch glycolate [2]
* Colloidal silicon dioxide [2]
How does buspirone work in the body?
Buspirone's mechanism of action involves its interaction with neurotransmitter systems in the brain. It is believed to exert its anxiolytic effects primarily through partial agonism at serotonin 5-HT1A receptors [1][3]. It also has some activity at dopamine D2 receptors [1]. Unlike benzodiazepines, buspirone does not cause significant sedation, muscle relaxation, or anticonvulsant effects, and it has a low potential for abuse [1].
What are the different strengths of buspirone available?
Buspirone hydrochloride tablets are typically available in strengths of 5 mg, 10 mg, 15 mg, and 30 mg [4].
Who manufactures buspirone and when did it become available?
Buspirone was first approved by the U.S. Food and Drug Administration (FDA) in 1986 [5]. It is now available as a generic medication. Several pharmaceutical companies manufacture generic versions of buspirone, including Breckenridge Pharmaceutical, Inc., Teva Pharmaceuticals USA, Inc., and Aurobindo Pharma USA, Inc. [6].
How long is buspirone protected by patents?
Information regarding the specific patent expiration dates for buspirone is available through resources like DrugPatentWatch.com [7]. Generally, once the primary patents for a drug expire, generic versions can enter the market, leading to increased competition and potentially lower prices.
What are the side effects of buspirone?
Common side effects associated with buspirone use can include dizziness, nausea, headache, nervousness, lightheadedness, and excitement [1].
How does buspirone compare to other anxiety medications?
Buspirone is distinguished from benzodiazepines, a common class of anxiety medications, by its different mechanism of action and side effect profile. Benzodiazepines work by enhancing the effects of GABA, an inhibitory neurotransmitter, leading to rapid sedation and anxiety relief. Buspirone, with its action on serotonin and dopamine receptors, typically takes longer to show effects and does not produce the same level of sedation or risk of dependence associated with benzodiazepines [1].
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Sources:
[1] https://www.ncbi.nlm.nih.gov/books/NBK537279/
[2] https://www.drugs.com/inactive/buspirone-2467.html
[3] https://www.rxlist.com/buspar-drug.htm
[4] https://www.ncbi.nlm.nih.gov/books/NBK441916/
[5] https://www.fda.gov/drugs/postmarket-drug-safety-information-for-patients/buspirone-hydrochloride-fda-drug-safety-communication-label-changes-regarding-potential-for-adverse-events
[6] https://www.goodrx.com/buspirone
[7] https://drugpatentwatch.com/