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Can alcohol increase Lipitor side effects? Alcohol and Lipitor (atorvastatin) can interact in ways that raise the risk of liver damage and muscle problems. Both substances place stress on the liver, and alcohol interferes with atorvastatin metabolism. When taken together, the drug stays longer in the body, boosting exposure and increasing the chance of myopathy or rhabdomyolysis. Why do patients ask about mixing Lipitor with wine specifically? Wine contains ethanol and often sugar, sugar-free versions contain sugar substitutes. Sugar-free versions may contain sorbitol or other polyols that can additional gastrointestinal upset. Sugar-free wine alternatives may also contain sugar substitutes that add to the already possible gastrointestinal side effects of atorvastatin. Sugar-free versions of wine may also contain sugar substitutes that add to the existing possible gastrointestinal side effects of atorvastatin.
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