See the DrugPatentWatch profile for crestor
Rosuvastatin calcium, the generic version of Crestor, is available on the market [1]. Crestor, manufactured by AstraZeneca, is a statin medication used to lower cholesterol and prevent heart disease [1][2].
When did generic Crestor become available?
The U.S. patent for Crestor expired in May 2020, which opened the door for generic versions to be manufactured and sold [1].
What are the common strengths of generic Crestor?
Generic rosuvastatin calcium is available in several dosages, typically including 5 mg, 10 mg, 20 mg, and 40 mg tablets [3].
Who manufactures generic rosuvastatin?
Numerous pharmaceutical companies produce generic rosuvastatin calcium. Some of these include Aurobindo Pharma, Cipla, Dr. Reddy's Laboratories, Mylan, and Teva Pharmaceuticals, among others [4].
How does generic Crestor compare to the brand-name version?
Generic rosuvastatin calcium is bioequivalent to brand-name Crestor, meaning it has the same active ingredient, dosage form, strength, and route of administration [5]. This ensures it is absorbed by the body and produces the same therapeutic effect [5]. The primary differences are typically in the inactive ingredients and, most notably, the cost, with generics usually being significantly less expensive [5].
What is the typical cost of generic Crestor?
The cost of generic rosuvastatin calcium can vary widely depending on the pharmacy, insurance coverage, and the specific dosage. However, it is generally considerably cheaper than brand-name Crestor [6].
What are the potential side effects of rosuvastatin?
Like the brand-name drug, generic rosuvastatin calcium can cause side effects. Common side effects include muscle pain, headache, nausea, and weakness [7]. More serious, though rare, side effects can include severe muscle problems (rhabdomyolysis) and liver damage [7]. Patients should discuss any concerns with their healthcare provider.
What are the indications for rosuvastatin?
Rosuvastatin is prescribed to treat high cholesterol levels, including hypercholesterolemia and mixed dyslipidemia [7]. It is also used to slow the progression of atherosclerosis in adult patients as part of a treatment strategy to lower cholesterol and raise HDL cholesterol [7]. Additionally, it is used to reduce the risk of stroke, heart attack, and other cardiovascular events in individuals with risk factors for heart disease [7].
What is the mechanism of action for rosuvastatin?
Rosuvastatin works by inhibiting HMG-CoA reductase, an enzyme that plays a key role in the liver's production of cholesterol [7]. By reducing cholesterol synthesis, it lowers levels of LDL ("bad") cholesterol and triglycerides, while increasing HDL ("good") cholesterol [7].
Sources:
[1] https://www.drugpatentwatch.com/
[2] https://www.crestor.com/
[3] https://www.goodrx.com/rosuvastatin
[4] https://www.generics.health/rosuvastatin-calcium-tablets-list-of-manufacturers-and-suppliers/
[5] https://www.fda.gov/drugs/generic-drugs/what-generic-drugs-are-and-how-they-got-approved
[6] https://www.singlecare.com/drugs/rosuvastatin
[7] https://www.mayoclinic.org/drugs-supplements/rosuvastatin-oral-route/description/drg-20073907