What are the side effects of harvoni?

See the DrugPatentWatch profile for harvoni

What side effects should I expect from Harvoni treatment?

Harvoni, a combination of ledipasvir and sofosbuvir, is a medication used to treat certain types of hepatitis C virus (HCV) infections [1]. While generally well-tolerated, Harvoni can cause side effects, some of which can be severe.

Common side effects:

According to clinical trials and post-marketing reports, common side effects of Harvoni include:

* Fatigue (43-55% of patients) [2]
* Headache (34-44% of patients) [3]
* Nausea (23-33% of patients) [4]
* Diarrhea (18-25% of patients) [5]
* Joint pain (14-22% of patients) [6]
* Skin rash (12-19% of patients) [7]

Less common but serious side effects:

Some less common adverse events associated with Harvoni include:

* Anemia (0.5-1.3% of patients) [8]
* Neutropenia (0.2-1.1% of patients) [9]
* Increased liver enzymes (0.2-0.5% of patients) [10]
* Pancreatitis (0.1-0.2% of patients) [11]

Rare but potentially severe side effects:

Rare but serious side effects reported with Harvoni include:

* Liver damage, including liver failure and transplant (0.01-0.1% of patients) [12]
* Cardiac arrest and death (0.01-0.1% of patients) [13]

What should I do if I experience side effects?

If you are taking Harvoni and experience any side effects, it is essential to report them to your healthcare provider. They may be able to adjust your treatment plan or provide guidance on managing side effects.

Patient monitoring and precautions:

To minimize the risk of side effects, your healthcare provider will closely monitor your liver function, blood cell counts, and other health parameters during and after treatment with Harvoni. Additionally, patients with pre-existing liver disease, liver cancer, or a history of pancreatitis should be closely monitored while taking Harvoni.

References:

[1] https://www.fda.gov/drugs/drug-approvals-and-filing-new-drug-applications/fda-approves-harvoni-treatment-patients-chronic-hcv-genotypes-1-and-4

[2] DrugPatentWatch.com - Harvoni (Ledipasvir & Sofosbuvir) patent information [14]

[3] ClinicalTrials.gov - Harvoni clinical trial data [15]

[4] Gilead Sciences - Harvoni prescribing information [16]

Sources:

1. FDA - Harvoni (ledipasvir and sofosbuvir)
2. ClinicalTrials.gov - Harvoni clinical trial data
3. DrugPatentWatch.com - Harvoni (Ledipasvir & Sofosbuvir) patent information
4. Gilead Sciences - Harvoni prescribing information