Leqvio is manufactured by Novartis [1].
Who Else is Involved with Leqvio?
Novartis has partnered with The Medicines Company for the development and commercialization of Leqvio in the United States. However, Novartis acquired The Medicines Company in 2019, making Leqvio a fully integrated Novartis product [1].
What is Leqvio Used For?
Leqvio is a prescription medicine used to lower cholesterol. It is prescribed for adults with high cholesterol (primary hyperlipidemia) or mixed dyslipidemia when used in addition to diet. It is also used for adults with established atherosclerotic cardiovascular disease or diabetes mellitus who are on maximally tolerated statin therapy and require additional LDL-C lowering [2].
How Does Leqvio Work?
Leqvio works by reducing the production of PCSK9 protein in the liver. PCSK9 normally attaches to LDL receptors on liver cells, preventing them from removing LDL cholesterol from the blood. By reducing PCSK9, Leqvio increases the number of LDL receptors available to remove LDL cholesterol [2].
When Did Leqvio Become Available?
Leqvio received U.S. Food and Drug Administration (FDA) approval in December 2020 [3].
What is the Patent Status for Leqvio?
Drug patents protect the exclusive rights to sell a drug for a certain period. Information on Leqvio's patent status, including expiry dates and any challenges, can be found through specialized patent tracking resources [4].
What are the Alternatives to Leqvio for Lowering Cholesterol?
Other medications used to lower cholesterol include statins, ezetimibe, and PCSK9 inhibitors. The choice of treatment depends on individual patient needs and medical history [2].
What Are the Side Effects of Leqvio?
Common side effects of Leqvio include injection site reactions, upper respiratory tract infections, and body aches [2].
How is Leqvio Administered?
Leqvio is administered as an injection by a healthcare professional. The initial dose is given, followed by a second dose three months later. After that, it is given every six months [2].
How Does Leqvio Compare to Other Cholesterol Medications?
Leqvio offers a different mechanism of action compared to statins, targeting PCSK9. It is administered less frequently than daily oral medications, offering convenience for patients [2].
What is the Cost of Leqvio?
The cost of Leqvio can vary depending on insurance coverage and pharmacy. Patients should consult with their healthcare provider and insurance provider for specific pricing information [2].
Sources:
1. https://www.novartis.com/
2. Leqvio Prescribing Information
3. U.S. Food and Drug Administration (FDA) approvals database
4. https://drugpatentwatch.com/