Naproxen is a widely available nonsteroidal anti-inflammatory drug (NSAID) [1]. Its patents have long expired, allowing for the production of generic versions [2].
When Did Naproxen Patents Expire?
The original patents for naproxen, developed by Syntex (now part of Hoffmann-La Roche), expired in the early 1990s [2]. This allowed for the introduction of generic naproxen to the market.
How Does Naproxen Work?
Naproxen works by blocking the action of cyclooxygenase (COX) enzymes [3]. These enzymes are responsible for producing prostaglandins, which are chemicals that contribute to inflammation, pain, and fever [3]. By inhibiting COX enzymes, naproxen reduces the production of prostaglandins, thereby alleviating these symptoms [3].
What Are the Different Forms of Naproxen Available?
Naproxen is available in various forms, including immediate-release tablets, delayed-release tablets, and liquid suspensions [4]. It is also often combined with other medications, such as decongestants or antacids [4]. These formulations are available both as prescription and over-the-counter medications [1].
What Conditions Does Naproxen Treat?
Naproxen is used to relieve pain, reduce inflammation, and lower fever [1]. It is commonly prescribed for conditions such as arthritis (including osteoarthritis and rheumatoid arthritis), gout, menstrual cramps, bursitis, tendonitis, and general pain [1].
What Are the Risks Associated with Naproxen?
Like other NSAIDs, naproxen carries risks, including stomach upset, ulcers, and bleeding [5]. Cardiovascular risks, such as heart attack and stroke, can also be increased with NSAID use [5]. Kidney problems and allergic reactions are other potential side effects [5]. It is important to use the lowest effective dose for the shortest duration necessary [5].
Are There Alternatives to Naproxen?
Other NSAIDs, such as ibuprofen and aspirin, are alternatives to naproxen [1]. Acetaminophen is another pain reliever that works differently and may be an option for individuals who cannot tolerate NSAIDs [1]. For inflammatory conditions, other classes of drugs may be considered depending on the specific diagnosis and severity [1].
Who Manufactures Generic Naproxen?
Numerous pharmaceutical companies manufacture generic versions of naproxen [2]. These companies include Teva Pharmaceuticals, Sandoz, and others, all of whom are able to produce the drug now that its primary patents have expired [2].