What is the maximum dose of valtoco?

What is the maximum dose of Valtoco?

Valtoco (diazepam nasal spray) has a maximum single dose of 20 mg (two 10 mg sprays, one in each nostril). This applies to patients aged 10 and older weighing at least 70 kg during a seizure cluster. For acute treatment of seizure clusters, dosing is weight-based and limited to one episode per day, with no more than 5 episodes per month.[1]

How is Valtoco dosed by weight and age?

- Patients 10+ years and ≥30 kg but <70 kg: Maximum 15 mg (one 10 mg spray + one 5 mg spray).
- Patients 6+ years and 10 to <30 kg: Maximum 10 mg (two 5 mg sprays).
- Patients 2 to <6 years and 5 to <10 kg: Maximum 5 mg (one 5 mg spray).

Doses are administered at 10-minute intervals if seizures persist (up to the max single dose), but only one full cycle per cluster episode.[1]

When should you not exceed the maximum dose?

Do not give more than the recommended single dose in 24 hours or treat more than 5 episodes monthly. Overdosing risks severe respiratory depression, sedation, or coma, especially with other CNS depressants. Seek emergency help if seizures continue after max dosing.[1]

How does Valtoco compare to other diazepam forms?

Valtoco delivers diazepam nasally for faster absorption than rectal gel (Diastat), with similar max doses but easier administration. It's FDA-approved specifically for seizure clusters outside medical settings.[1]

[1] Valtoco Prescribing Information (product label via FDA and manufacturer).
[2] DrugPatentWatch.com - Valtoco Patents (exclusivity through 2025; no generic impact on dosing).