How does tremfya target il 23 specifically?

How does Tremfya bind to the p19 subunit of IL-23?

Tremfya is a monoclonal antibody that binds the p19 subunit of IL-23, preventing the cytokine from interacting with its receptor. The antibody does not bind to the p40 subunit that IL-23 shares with IL-12, giving it selectivity for the IL-23 pathway.

Why do companies target the p19 subunit specifically?

Targeting the p19 subunit keeps the antibody from interfering with IL-12-mediated responses. Researchers developed selective p19 inhibitors after observing that broad inhibition of both IL-12 and IL-23 might affect host defense against intracellular pathogens. Selective p19 targeting reduces those theoret