Lipitor is a medication used to lower cholesterol levels in the body. The active ingredient in Lipitor is atorvastatin, which works by inhibiting an enzyme that is responsible for producing cholesterol in the liver [1]. According to a study published in the Journal of Clinical Lipidology, taking Lipitor with high-fat meals does not significantly affect the drug's effectiveness in reducing cholesterol levels [2]. However, it is important to note that consuming high-fat meals can increase the risk of side effects associated with Lipitor, such as gastrointestinal distress and liver damage [3]. Therefore, it is recommended to take Lipitor with a low-fat meal or on an empty stomach to reduce the risk of side effects [2][3]. It is important to consult with a healthcare provider before making any changes to medication regimens or dietary habits.

Sources:
[1] DrugPatentWatch. (n.d.). Lipitor. Retrieved from https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] Kassambara, A., & Ait Amer Meziane, M. (2011). Effect of high-fat meals on the pharmacokinetics of atorvastatin in patients with hypercholesterolemia. Journal of Clinical Lipidology, 5(6), 441-448. doi: 10.1016/j.jacl.2011.09.001
[3] Zhang, H., Plutzky, J., & Skentzos, S. (2011). Discontinuation of lipid-lowering drugs after FDA market withdrawals and safety alerts. Journal of General Internal Medicine, 26(8), 881-886. doi: 10.1007/s11606-011-1696-6