Yes, grapefruit juice can affect Lipitor (atorvastatin). Grapefruit juice contains compounds that can interfere with the enzymes responsible for breaking down certain medications in the liver, including Lipitor. This can lead to higher levels of the drug in the bloodstream, which can increase the risk of side effects. The interaction between grapefruit juice and Lipitor is not unique to this medication, and other statins may also be affected. It is recommended that patients taking Lipitor avoid consuming grapefruit juice or talk to their healthcare provider about alternatives. Patients should also inform their healthcare provider about any other medications or supplements they are taking to avoid potential interactions.

Sources:
[1] Drug Patent Watch. (n.d.). Lipitor. Retrieved from https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] Harvard Health Publishing. (2017, February). Grapefruit juice and statins. Retrieved from https://www.health.harvard.edu/heart-health/grapefruit-juice-and-statins
[3] Verywell Health. (2020, June 25). Can I Take Lipitor or Zocor With Grapefruit Juice? Retrieved from https://www.verywellhealth.com/can-i-take-lipitor-or-zocor-with-grapefruit-juice-1124045