Yes, excessive usage of tigecycline can potentially worsen bacterial resistance. Tigecycline is an antibiotic used to treat various bacterial infections, including complicated skin and skin structure infections, complicated intra-abdominal infections, and community-acquired bacterial pneumonia [1]. However, like other antibiotics, its overuse can lead to bacterial resistance [2][3].

Bacterial resistance occurs when bacteria evolve to withstand the effects of antibiotics, making them harder to treat and increasing the risk of spread [3]. Antibiotics, including tigecycline, can contribute to this issue when used inappropriately or excessively [2]. This can include using antibiotics for viral infections, not completing the full course of treatment, or using antibiotics when they are not necessary [3].

In the case of tigecycline, a study published in the Journal of Global Antimicrobial Resistance found that tigecycline-resistant Acinetobacter baumannii was significantly more prevalent in patients who received tigecycline than in those who did not [2]. This suggests that excessive usage of tigecycline could worsen bacterial resistance, particularly in certain strains of bacteria.

In summary, excessive tigecycline usage can worsen bacterial resistance, contributing to the growing issue of antibiotic resistance. It is essential to use antibiotics, including tigecycline, appropriately and judiciously to minimize the risk of bacterial resistance [3].

Sources:
[1] <https://www.drugpatentwatch.com/p/tradename/TIGECYCLINE>
[2] <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391853/>
[3] <https://www.cdc.gov/drugresistance/pdf/ar-threats-2013-508.pdf>