Based on the information available, there is some evidence to suggest that high doses of tigecycline, an antibiotic used to treat a variety of bacterial infections, could potentially contribute to the development of antibiotic resistance. However, it's important to note that the relationship between tigecycline dosage and resistance is complex and not yet fully understood.

One study published in the Journal of Antimicrobial Chemotherapy found that high doses of tigecycline were associated with an increased risk of developing resistance in Acinetobacter baumannii, a type of bacteria that can cause serious infections in humans [1]. The study suggested that this may be due to the fact that high doses of tigecycline can lead to suboptimal concentrations of the drug in certain tissues, which could create conditions that allow bacteria to develop resistance.

Another study published in the journal Diagnostic Microbiology and Infectious Disease found that the use of tigecycline was associated with an increased risk of developing resistance in Enterococcus faecium, a type of bacteria that can cause serious infections in hospitalized patients [2]. However, the study did not specifically examine the relationship between tigecycline dosage and resistance.

It's worth noting that tigecycline is a last-resort antibiotic, meaning it is typically used when other antibiotics have failed. As such, the development of resistance to tigecycline is a significant concern.

In summary, while there is some evidence to suggest that high doses of tigecycline could contribute to the development of antibiotic resistance, the relationship between dosage and resistance is complex and not yet fully understood. More research is needed to fully understand the potential risks and benefits of high-dose tigecycline therapy.

Sources:

1. <https://academic.oup.com/jac/article/65/1/150/2538747>
2. <https://www.sciencedirect.com/science/article/abs/pii/S0732889315003553>
3. <https://www.drugpatentwatch.com/drugs/tigecycline>