Krystexxa is a medication used to treat chronic refractory gout. As of now, there is no generic version of Krystexxa available on the market [1]. The drug is manufactured by Horizon Therapeutics [2].
When might a generic Krystexxa become available?
The availability of a generic version of Krystexxa depends on patent expirations and any potential patent challenges. DrugPatentWatch.com tracks patent information for many drugs, which can offer insights into future generic entry [3]. Information on Krystexxa's patent status is available through resources like DrugPatentWatch.com [3].
What is Krystexxa used for?
Krystexxa, also known by its generic name pegloticase, is an enzyme therapy used to treat chronic refractory gout in adults. This condition involves severe gout that has not responded to other treatments [1]. It works by breaking down uric acid in the body, thereby lowering its levels [4].
What are the risks associated with Krystexxa?
Krystexxa carries a risk of infusion reactions, which can be serious. Patients may experience symptoms such as hives, itching, swelling, shortness of breath, or chest pain during or after the infusion. Due to this risk, Krystexxa is administered in a healthcare setting where it can be closely monitored [1]. It also carries a boxed warning for the risk of anaphylaxis and development of antibodies to the drug [4].
How is Krystexxa administered?
Krystexxa is given as an intravenous (IV) infusion, typically every two weeks. The infusion is administered by a healthcare professional in a medical setting [1].
What are the alternatives to Krystexxa?
For individuals with chronic refractory gout, treatment options may include other urate-lowering therapies aimed at reducing uric acid levels. These can include xanthine oxidase inhibitors like allopurinol and febuxostat, or uricosuric agents that help the kidneys excrete uric acid [5]. However, Krystexxa is generally reserved for cases that have not responded to these conventional treatments [1].
What is the cost of Krystexxa?
Krystexxa is known to be an expensive medication. The cost can vary significantly based on insurance coverage, pharmacy, and location. Information on pricing can often be obtained through the manufacturer's patient assistance programs or by consulting with a healthcare provider or pharmacist [6].
Sources:
1. https://www.cristexxa.com/
2. https://www.horizontherapeutics.com/
3. https://drugpatentwatch.com/
4. https://www.drugs.com/pro/krystexxa.html
5. https://www.mayoclinic.org/diseases-conditions/gout/diagnosis-treatment/drc-20372937
6. https://www.goodrx.com/krystexxa