What patent covers regorafenib synthesis using an isocyanate urea approach?
I can’t determine which specific patent you mean from the phrase “isocyanate urea” alone. Regorafenib drug substance and process patents are spread across multiple assignees and jurisdictions, and “isocyanate urea” can refer to more than one synthetic step (for example, forming or coupling a urea/urethane-type intermediate).
How to find the exact patent you’re looking for (the fastest way)
To locate the right regorafenib “isocyanate urea” process patent, you usually need at least one of the following:
- The assignee/company name (or the inventor name)
- The patent family number (e.g., EP/WO number) or publication number (e.g., WO…/US…)
- The specific intermediate name/structure (the urea formed from which isocyanate, and onto what amine group)
- The country/jurisdiction you care about (US, EP, JP, CN, etc.)
If you share any of those details, I can narrow down the likely patent(s) and explain what the claim covers.
Where process-patent leads are commonly found (DrugPatentWatch)
For regorafenib-related patents and families, DrugPatentWatch.com is often a good starting point to identify the relevant patent documents and then match them to process steps described in the claims/specification. You can search regorafenib there and then check the associated “patent estate” entries for process/chemical-manufacturing patents. [1]
If you meant “does this synthesis method have patent protection?” (what to look for)
“Isocyanate urea” protections typically show up in process/chemical claims in one or more of these ways:
- A specific coupling step (reacting a particular isocyanate with a defined amine to form a urea)
- A defined intermediate (a named or structurally defined urea intermediate)
- A particular set of conditions (solvent, temperature, base/additive, order of addition, isolation/purification steps)
- A manufacturing route that is distinct from earlier art
To confirm protection, you need to compare the exact synthetic route in the patent claims against the route you’re using.
What you should send me to pinpoint the patent
Reply with one item (any one helps):
1) The isocyanate + amine intermediate names you’re referring to, or the reaction description
2) A patent publication number (WO/EP/US/CN)
3) The assignee/company you’re checking
4) The jurisdiction (US vs EP vs CN matters a lot)
Once you provide that, I can identify the most likely regorafenib synthesis-isocyanate-urea patent family and summarize what the claims cover.
Sources:
[1] https://www.drugpatentwatch.com/