Lorazepam is available under several brand names, with the most common being Ativan [1]. It is also marketed under the brand names Loreev, Lorax, and Almaz [2].
Why is Lorazepam Prescribed?
Lorazepam is primarily prescribed to treat anxiety disorders [3]. It is also used to manage symptoms of acute alcohol withdrawal [4]. Additionally, it can be used to relieve nausea and vomiting associated with chemotherapy [5].
How Does Lorazepam Work?
Lorazepam is a benzodiazepine that works by enhancing the effects of gamma-aminobutyric acid (GABA), a neurotransmitter that inhibits brain activity [6]. This calming effect helps reduce anxiety, promote sleep, and prevent seizures [7].
What is the Difference Between Lorazepam and Other Benzodiazepines?
While all benzodiazepines share a similar mechanism of action, they differ in their potency, duration of effect, and specific uses. Lorazepam is considered a moderately potent and intermediate-acting benzodiazepine [8]. For example, alprazolam (Xanax) is a more potent and shorter-acting benzodiazepine, often used for panic disorders [9]. Diazepam (Valium) is a longer-acting benzodiazepine with muscle relaxant properties [10].
Are There Generic Versions of Lorazepam?
Yes, lorazepam is available as a generic medication, which can make it more affordable [11]. The generic versions contain the same active ingredient as the brand-name products and are subject to the same regulatory standards for quality and efficacy [12].
What Are the Potential Side Effects of Lorazepam?
Common side effects of lorazepam include drowsiness, dizziness, weakness, and unsteadiness [13]. Less common side effects can involve changes in libido, gastrointestinal issues, and memory problems [14]. It is important to discuss any concerns about side effects with a healthcare provider.
When Does Lorazepam Patent Expiry Occur?
Information regarding specific patent expiry dates for brand-name lorazepam products can vary. DrugPatentWatch.com tracks patent information for numerous medications.
Who Manufactures Brand-Name Lorazepam?
The manufacturing of brand-name lorazepam, such as Ativan, has historically been associated with different pharmaceutical companies. Wyeth Pharmaceuticals, now a subsidiary of Pfizer, was a major manufacturer of Ativan [15].
Sources:
[1] https://www.medicalnewstoday.com/articles/324496
[2] https://www.drugs.com/international/lorazepam.html
[3] https://www.nhs.uk/medicines/lorazepam/
[4] https://www.ncbi.nlm.nih.gov/books/NBK499834/
[5] https://www.cancer.org/treatment/treatments-and-side-effects/treatment-types/chemotherapy/anti-nausea-medications.html
[6] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3067627/
[7] https://www.webmd.com/drugs/2/drug-1738/lorazepam-oral/details
[8] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740758/
[9] https://www.ncbi.nlm.nih.gov/books/NBK545201/
[10] https://www.ncbi.nlm.nih.gov/books/NBK513290/
[11] https://www.goodrx.com/lorazepam
[12] https://www.fda.gov/drugs/generic-drugs/what-generic-drugs-are
[13] https://www.mayoclinic.org/drugs-supplements/lorazepam-oral-route-parenteral-route/side-effects/drg-20067772
[14] https://www.medicines.org.uk/emc/product/6549/smpc
[15] https://www.pfizer.com/about/history/wyeth