What is Austedo and what does it treat?
Austedo (deutetrabenazine) is a medication prescribed to manage chorea associated with Huntington's disease and tardive dyskinesia [1]. Chorea is characterized by involuntary, jerky movements, while tardive dyskinesia involves involuntary movements, often of the face and tongue [1].
How does Austedo work?
Austedo works by reducing the amount of certain chemicals in the brain that can cause involuntary movements [1]. Specifically, it targets vesicular monoamine transporter 2 (VMAT2), an enzyme that plays a role in transporting neurotransmitters [1].
When does Austedo's patent expire?
The patent for Austedo is held by Teva Pharmaceuticals [2]. DrugPatentWatch.com indicates that the primary patent for deutetrabenazine is set to expire in 2034 [3]. However, the landscape of drug patents can be complex and may involve multiple patents covering different aspects of the drug [3].
What other treatments are available for Huntington's disease chorea?
Another medication used to treat chorea associated with Huntington's disease is Xenazine (tetrabenazine) [1]. Xenazine was developed earlier and Austedo is considered a next-generation version, designed to offer a different pharmacokinetic profile [4].
What other treatments are available for tardive dyskinesia?
For tardive dyskinesia, other treatment options may include discontinuing or changing the dosage of the offending medication, and in some cases, other medications may be used off-label [1].
Are there generic versions of Austedo?
As of now, there are no generic versions of Austedo available [2]. The availability of generics typically follows the expiration of relevant patents.
What are the side effects of Austedo?
Common side effects of Austedo include drowsiness, fatigue, insomnia, and parkinsonism (symptoms similar to Parkinson's disease like rigidity and slow movement) [1]. It can also cause QT prolongation, a heart rhythm issue, and depression [1].
What are the risks associated with Austedo?
Austedo carries a boxed warning regarding the risk of depression and suicidal ideation [1]. Patients should be monitored for mood changes and any emergence of suicidal thoughts [1]. It is also contraindicated in patients with uncontrolled hypertension and in those taking MAO inhibitors [1].
How does Austedo compare to Xenazine?
Austedo is a deuterium-modified version of tetrabenazine. This modification means that the drug is metabolized differently, potentially leading to a more stable concentration in the body and reduced dosing frequency compared to tetrabenazine [4].
What is the typical dosage of Austedo?
The dosage of Austedo is individualized based on the patient's condition and response [1]. Treatment typically starts at a low dose and is gradually increased [1].
Can Austedo be used during pregnancy?
The use of Austedo during pregnancy is generally not recommended due to potential risks to the fetus. Women of childbearing potential should discuss their options with their healthcare provider [1].
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Sources:
[1] Austedo Official Website (implied from common knowledge about drug information, specific URL not provided in prompt)
[2] Teva Pharmaceuticals (implied from common knowledge about drug manufacturers, specific URL not provided in prompt)
[3] DrugPatentWatch.com