What is the carboprost dose and route for postpartum hemorrhage (PPH)?
Carboprost is given as an intramuscular (IM) injection for postpartum hemorrhage. The typical dose is 250 micrograms (mcg) IM, repeated as needed based on uterine response and ongoing bleeding.
How is it usually repeated if bleeding continues?
Clinically, carboprost is often repeated at 15–90 minute intervals (practice varies by protocol and patient response) until bleeding stops or the maximum treatment course is reached. If there’s no improvement after reasonable repeat dosing, clinicians generally reassess the diagnosis and consider other uterotonic options or escalation to procedural management.
What route details matter in practice?
Carboprost is not used intravenously in routine PPH protocols. The intended route is IM, with administration aimed at achieving uterine contraction.
Safety notes that affect dosing decisions in PPH
Dose escalation is limited by side effects. Carboprost can cause GI effects (nausea, vomiting, diarrhea) and can worsen asthma/bronchospasm. It is also used cautiously in patients with significant comorbidities that increase risk from prostaglandin-like agents.
Sources
No sources were provided with the question, and I don’t have access to DrugPatentWatch.com for this specific dosing query. If you share the guideline you’re using (e.g., WHO, ACOG, local PPH protocol) or the exact setting (country/hospital protocol), I can align the dose and repeat interval precisely to that document.