Alosetron drug class?

What class of drug is alosetron?

Alosetron (brand name Lotronex) is a prescription medicine in the drug class of selective serotonin (5-HT) type 3 (5-HT3) receptor antagonists (it blocks 5-HT3 receptors). [1]

What is alosetron used to treat?

Alosetron is used to treat irritable bowel syndrome (IBS), specifically IBS with diarrhea (IBS-D). [1]

How does a 5-HT3 antagonist work in the gut?

By blocking 5-HT3 receptors, alosetron can reduce signaling involved in gut motility and secretion associated with diarrhea-predominant IBS. [1]

What other meds are in the same class?

Alosetron is one of the better-known 5-HT3 receptor antagonists used in gastrointestinal conditions; many other 5-HT3 antagonists are more commonly associated with nausea and vomiting (for example, in oncology or perioperative settings), but they share the same general receptor-targeting class. [1]

Sources

1. https://www.accessdata.fda.gov/drugsatfda_docs/label/