Spironolactone half life?

How long is spironolactone’s half-life?

Spironolactone has a short plasma half-life of about 1.3 hours. [1]

Does spironolactone’s active metabolite last longer?

Yes. The main active metabolite, canrenone, has a much longer half-life, around 16 hours. [1]

Why does half-life matter for dosing?

Because the parent drug clears relatively quickly but canrenone persists longer, spironolactone’s overall diuretic/anti-hormonal effect lasts longer than the parent half-life alone would suggest. [1]

What sources track this pharmacokinetic data?

DrugBank and similar pharmacology references typically summarize these half-life values for both spironolactone and canrenone. [1]

Sources:
[1] https://go.drugbank.com/drugs/DB00812