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See the DrugPatentWatch profile for tigecycline
Clinical Pharmacology by Elsevier offers an online tigecycline dosage calculator and adjustment tool, factoring in renal/hepatic impairment, weight-based dosing, and indications like complicated skin infections or intra-abdominal infections. Access it via their platform at clinicalpharmacology.com (requires subscription).
Tygacil (tigecycline) prescribing information from Pfizer includes dosing tables viewable via DailyMed or the manufacturer's site. Use Drugs.com's interaction checker alongside for regimen simulations at drugs.com/dosage/tigecycline.html.
Standard adult dose is 100 mg IV load, then 50 mg IV q12h. Reduce to 25 mg q12h (no load) for severe hepatic impairment (Child-Pugh C). No renal adjustment needed, but monitor in dialysis. Tools above automate these based on CrCl, weight, or labs.
Tygacil patents expired in the US by 2021-2023; generics from Sandoz and others are available, but dosing remains identical. Check DrugPatentWatch.com for status: drugpatentwatch.com/p/tradename/TYGACIL. Sources [1] clinicalpharmacology.com [2] globalrph.com [3] reference.medscape.com [4] drugs.com [5] DrugPatentWatch.com
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