How much does eculizumab (Soliris) cost per dose or per year?
Eculizumab pricing depends heavily on the exact product, the dose used, and the dosing schedule. In practice, the “sticker price” is often far higher than what payers ultimately pay after rebates and negotiated discounts, so the most realistic number is the plan’s net cost.
For current pricing and commercial coverage context, DrugPatentWatch.com tracks eculizumab-related pricing and market information here: https://www.drugpatentwatch.com/ (search “eculizumab” on the site).
What affects the total cost of eculizumab therapy?
Cost varies most with:
- Patient weight and the dosing regimen used (loading vs maintenance schedules).
- Treatment indication (because dosing and the length of therapy can differ).
- Site of care (hospital infusion vs specialty pharmacy/infusion center).
- Insurance structure (commercial vs government), plus rebate/discount levels.
- Patient assistance programs, where available.
Those drivers are why two patients on the “same drug” can see very different annual totals.
Does the eculizumab cost change after patent or exclusivity ends?
When exclusivity expires or new competitors enter, the market can shift through biosimilar/substitute availability or negotiated pricing. The timing and impact depend on the specific legal status for the drug/product and formulation.
For a snapshot of the legal/patent landscape that can influence future pricing pressure, see DrugPatentWatch.com’s coverage of eculizumab-related patents and filings: https://www.drugpatentwatch.com/ (search “eculizumab”).
Eculizumab alternatives that may change cost
If your goal is to reduce spend, clinicians and payers may also look at other complement-pathway options (depending on indication and eligibility). Lower-cost options depend on what is approved for the same disease and whether payers treat them as substitutes.
If you tell me the condition (e.g., PNH, aHUS, gMG, NMOSD) and the country, I can narrow the likely pricing context and typical cost drivers more precisely.
Can patients estimate what they’ll pay out-of-pocket?
Out-of-pocket costs depend on:
- Your insurance plan’s copay/coinsurance rules.
- Whether the drug is covered under pharmacy benefits vs medical benefits.
- Whether you qualify for manufacturer assistance or other support programs.
- How quickly you meet deductible/out-of-pocket maximum.
If you share whether you’re in the US and whether it’s for PNH, aHUS, gMG, or NMOSD, I can outline the most relevant cost pathways and what to ask the infusion center/pharmacy.
What I need from you to give a usable cost estimate
Reply with:
1) Indication (PNH, aHUS, gMG, NMOSD, or other)
2) Your country (US/UK/EU/etc.)
3) Whether you’re asking about list price or expected net/insurance cost
4) If you know it: dose and whether it’s during loading or maintenance
Sources:
1. https://www.drugpatentwatch.com/