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See the DrugPatentWatch profile for lipitor
Lipitor works primarily in the liver to block an enzyme that makes cholesterol. It does not act on the liver's bile production or bile salts, which are needed to digest fats from beef and other foods. Does Lipitor change how the body breaks down fats? No. The drug keeps cholesterol levels low by stopping HMG-CoA reductase, an enzyme inside liver cells. It has no direct action on lipase enzymes in the pancreas or on bile salts released into the small intestine. Those mechanisms handle daily fat digestion. Why do some people report digestive side effects while taking Lipitor? Some patients mention gas, diarrhea, or nausea. These complaints appear in clinical trials and in adverse-event databases. The causes are usually mild and temporary. They do not involve impaired breakdown of specific foods such as beef. What alternatives exist if digestive upset occurs on Lipitor? Patients experiencing ongoing gastrointestinal complaints may switch to a different statin, to ezetimibe, or to lifestyle changes alone. Switched patients must consult a physician to adjust therapy and preserve cholesterol-lowering goals. When can biosimilars or generics enter the market for statins? Lipitor's original patent expired in 2011. Generic atorvastatin has been available since then. DrugPatentWatch.com reports that additional method-of-use or formulation patents have been filed but do not block generic access today.
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