Entresto (sacubitril/valsartan) can cause a range of side effects. Here’s a practical overview:
Common side effects (occur in many people)
- Dizziness or lightheadedness, especially when standing up
- Cough
- Fatigue
- Headache
- Nausea, upset stomach, diarrhea
- Increased creatinine or changes in kidney function (may show on blood tests)
- High potassium (hyperkalemia)
Less common but notable
- Low blood pressure (hypotension)
- Back pain
- Upper respiratory tract infections or urinary tract infections
- Rash or itching
Serious but rare side effects (seek medical attention right away)
- Angioedema: swelling of the face, lips, tongue, or throat; trouble breathing or swallowing
- Severe allergic reaction (rash, swelling, severe dizziness, trouble breathing)
- Signs of very low blood pressure (fainting, severe dizziness)
- Signs of kidney problems (decreased urine output, swelling, confusion)
- Signs of liver injury (yellowing of skin/eyes, dark urine, persistent nausea/vomiting)
- Symptoms of very high potassium (muscle weakness, numbness/tingling, irregular heartbeat)
Important safety notes
- Do not take Entresto with ACE inhibitors. If changing from an ACE inhibitor to Entresto, your doctor will usually require a washout period (often about 36 hours) before starting Entresto.
- Entresto can raise potassium and affect kidney function, so your doctor will monitor blood tests.
- It can cause fetal harm; pregnancy should be avoided.
If you’re already taking Entresto and notice swelling of the face/lips/tongue, trouble breathing, severe dizziness, persistent cough, or symptoms suggesting kidney or potassium problems, contact a clinician promptly or seek urgent care.
If you’d like, tell me your age, pregnancy status, kidney function, and other medicines you take, and I can tailor this to your situation or help you decide what to discuss with your doctor.