Propranolol became available as a generic medication in the United States in 1984 [1].
When did the first generic version of propranolol become available?
The first generic version of propranolol was launched in 1984 [1]. This marked the point at which the drug, originally marketed under brand names like Inderal, was no longer exclusively available through patent protection.
What is propranolol used for?
Propranolol is a beta-blocker medication used to treat a variety of conditions. These include high blood pressure, chest pain (angina), irregular heart rhythms, and to prevent further heart attacks after a heart attack [2]. It is also used to treat tremors, anxiety symptoms such as a rapid heartbeat, and to prevent migraine headaches [2].
How does propranolol work?
As a beta-blocker, propranolol works by blocking the effects of epinephrine (adrenaline) and other stress hormones. This causes the heart to beat more slowly and with less force, which lowers blood pressure and reduces the heart's workload [2]. It also affects blood vessels, causing them to widen [2].
What are the brand names associated with propranolol?
Propranolol was originally marketed under brand names, most notably Inderal [1]. Other brand names have also been used for formulations of propranolol [2].
When do drug patents typically expire?
Drug patents in the United States generally last for 20 years from the date the patent application was filed [3]. However, this term can be extended through various mechanisms, such as patent term restoration, to compensate for delays in regulatory review [3]. The expiration of a patent allows generic versions of the drug to enter the market [3].
How does patent expiration affect drug pricing?
Once a brand-name drug loses patent protection and generic alternatives become available, the price of the medication typically decreases significantly. This is due to competition among multiple manufacturers producing the generic version [3].
Where can I find information on drug patent expirations?
Information on drug patent expirations, including for medications like propranolol, can be found on resources such as DrugPatentWatch.com [4]. These platforms track patent filings, expiration dates, and other relevant data for pharmaceutical products.
Are there different forms of propranolol?
Yes, propranolol is available in various forms, including immediate-release and extended-release capsules and tablets, as well as an oral solution [2].
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**Sources:
[1] https://www.drugpatentwatch.com/
[2] https://www.mayoclinic.org/drugs-supplements/propranolol-oral-route/description/drg-20067007
[3] https://www.fda.gov/about-fda/center-drug-evaluation-and-research-cder/drug-marketing-approval-process-facts-and-comparison
[4] https://www.drugpatentwatch.com/