The decision to stop bosentan, a medication used to treat pulmonary arterial hypertension, should be made in consultation with a healthcare provider and depends on various factors. These factors may include the patient's response to treatment, potential side effects, and the availability of alternative treatment options.
Bosentan, like other medications, has potential side effects that may impact a patient's decision to continue or discontinue its use. Common side effects of bosentan include headache, anemia, and liver enzyme elevations [1]. Regular monitoring of liver function is recommended while taking bosentan due to the potential for liver injury [1]. If a patient experiences severe or persistent side effects, or if liver function tests consistently exceed three times the upper limit of normal, it may be necessary to consider stopping bosentan [1].
Additionally, the patient's response to treatment should be evaluated periodically. If bosentan is not providing the desired therapeutic effect, or if alternative treatment options become available, discontinuation of bosentan may be appropriate [2].
It is important to note that abruptly stopping bosentan is not recommended due to the risk of rebound pulmonary hypertension [1]. Therefore, any decision to stop bosentan should be made in consultation with a healthcare provider and should be done gradually, under medical supervision.
In summary, the decision to stop bosentan should be based on a variety of factors, including the patient's response to treatment, potential side effects, and the availability of alternative treatment options. Regular monitoring and communication with a healthcare provider are crucial when considering changes to medication regimens.
Sources:
[1] Bosentan (Oral Route) Side Effects - Mayo Clinic. (n.d.). Retrieved March 28, 2023, from <https://www.mayoclinic.org/drugs-supplements/bosentan-oral-route/side-effects/drg-20063041?p=1>
[2] DrugPatentWatch. (n.d.). Bosentan. Retrieved March 28, 2023, from <https://www.drugpatentwatch.com/drugs/bosentan>