What side effects can happen with Rinvoq 15 mg (upadacitinib)?
Rinvoq (upadacitinib) can cause side effects in some people. Commonly reported effects include infections (such as upper respiratory infections), nausea, and changes in lab tests (like blood counts). [1][2]
Because Rinvoq affects the immune system, some side effects are serious and need prompt medical attention, including infections that become severe or unusual. [1][2]
What serious side effects should I watch for?
People taking Rinvoq need to watch for warning signs of serious problems, including:
- Serious infections (symptoms may include fever, chills, persistent cough, or feeling very unwell). [1][2]
- Blood clots (for example, leg swelling or pain, chest pain, trouble breathing). [1][2]
- Increased risk of cardiovascular events (symptoms can include chest pain or sudden weakness). [1][2]
- Cancer (new or worsening symptoms should be reported promptly). [1][2]
If any of these occur, seek urgent medical care.
How do lab-test changes show up, and why do they matter?
Rinvoq can change key blood and immune markers. Clinicians typically monitor labs during treatment, including:
- Neutrophils and other blood counts (low levels can increase infection risk). [1][2]
- Lipids (cholesterol and related measures may rise). [1][2]
- Liver-related tests (liver enzymes may increase). [1]
These changes may not cause symptoms at first, which is why routine bloodwork is important. [1][2]
Are there differences in side effects between 15 mg and other Rinvoq doses?
Rinvoq’s overall side-effect pattern comes from the same active drug (upadacitinib). Higher doses can increase exposure, which may raise risk for certain events. Dose-specific side effects are not listed here, so the safest approach is to follow the warnings and monitoring plan tied to your prescribed dose and medical history. [1][2]
What should you do if you miss a dose or stop Rinvoq?
This medication is usually continued under a prescriber’s guidance for chronic conditions. Stopping suddenly can let symptoms of the underlying disease return. If you’re having side effects, contact your clinician before stopping so they can advise whether to hold the medication, treat the side effect, or adjust therapy. [1][2]
When should you call your doctor urgently?
Call urgently or seek emergency care if you have signs of a serious infection (fever, feeling severely ill, trouble breathing), symptoms suggestive of a blood clot (one-sided leg swelling/pain, chest pain, sudden shortness of breath), or other severe reactions. [1][2]
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Sources
[1] https://www.rxlist.com/rinvoq-side-effects-drug.htm
[2] https://www.medicines.org.uk/emc/product/9185/smpc