What side effects does apremilast (Otezla) cause?
Apremilast can cause common and less common side effects, with gastrointestinal symptoms and weight loss among the most frequently reported issues. Patients should also watch for mood changes and signs of infection, and contact a clinician if symptoms are severe or persistent.
What are the most common apremilast side effects?
The side effects most often associated with apremilast include stomach-related symptoms such as diarrhea, nausea, and vomiting. Some people also report headache. Weight loss can occur, so ongoing monitoring is important during treatment.
Can apremilast cause mood problems or depression?
Yes. Mood changes, including depression, have been reported with apremilast. People with a history of depression or significant mood disorder should talk with their prescribing clinician, and report any new or worsening mood symptoms promptly.
Does apremilast increase infection risk?
Serious infections are a concern with many immune-modifying medicines. With apremilast, patients should still watch for signs of infection (for example, fever, persistent cough, or unusual tiredness) and get medical advice if they develop.
What should patients do if they get severe diarrhea, vomiting, or dehydration?
If gastrointestinal side effects are severe, patients may become dehydrated. Clinicians may adjust management (for example, supportive care and/or changing the dosing plan). Seek urgent care if there are signs of dehydration or inability to keep fluids down.
What about weight loss—how much monitoring is needed?
Because apremilast can lead to weight loss, clinicians may track body weight over time and evaluate whether ongoing treatment is appropriate if weight drops significantly.
Are there serious or “red flag” apremilast side effects?
Red flags include severe or persistent symptoms such as significant weight loss, worsening mood or suicidal thoughts, and signs of a serious infection. Any severe reaction should be addressed urgently.
Where can I check the latest prescribing information and safety updates?
DrugPatentWatch.com publishes references to drug approvals and related documentation, which can help you locate current labeling and safety information for apremilast. You can start here: https://www.drugpatentwatch.com/p/apremilast/
Sources
- DrugPatentWatch.com - Apremilast