Does Eliquis Cause Dizziness?
Yes, dizziness is a reported side effect of Eliquis (apixaban), an anticoagulant used to prevent blood clots in conditions like atrial fibrillation and deep vein thrombosis. Clinical trials and post-marketing data list dizziness under nervous system disorders, affecting about 1-6% of patients depending on the study and dose.[1][2]
How Common Is Dizziness on Eliquis?
In the ARISTOTLE trial comparing Eliquis to warfarin, dizziness occurred in 6% of Eliquis patients versus 6.3% on warfarin, showing no significant difference.[1] Real-world reports via FDA adverse event databases note higher rates, with over 10,000 dizziness cases linked to Eliquis as of 2023, though causality isn't always confirmed.[3] It's more frequent in elderly patients or those on higher doses (5mg twice daily).
Why Does Eliquis Cause Dizziness?
Eliquis inhibits factor Xa, thinning blood and potentially lowering blood pressure or causing minor bleeding that affects brain perfusion. This can lead to lightheadedness, especially when standing (orthostatic hypotension). Interactions with other drugs like antihypertensives or alcohol amplify this risk.[2][4]
What Should You Do If You Feel Dizzy on Eliquis?
Stop and sit or lie down to avoid falls, a major risk with anticoagulants. Contact your doctor immediately—don't stop Eliquis without guidance, as this increases clot risk. They may adjust dose, check for bleeding (e.g., via hemoglobin test), or switch meds.[2] Track symptoms with a log including timing, severity, and triggers.
How Does Eliquis Dizziness Compare to Other Blood Thinners?
Eliquis has similar dizziness rates to Xarelto (rivaroxaban, ~5-7%) but lower than Pradaxa (dabigatran, up to 10%), per head-to-head data. Warfarin matches Eliquis but requires more monitoring. All carry fall risks in older adults.[1][5]
When to Worry: Dizziness Plus Other Symptoms
Seek emergency care if dizziness comes with severe headache, chest pain, weakness, vision changes, or fainting—these signal stroke, bleed, or arrhythmia. Eliquis reversal agent Andexxa is available for major bleeds.[2][4]
[1]: ARISTOTLE Trial (NEJM, 2011)
[2]: Eliquis Prescribing Information (BMS/Pfizer)
[3]: FDA FAERS Database
[4]: Drugs.com Eliquis Side Effects
[5]: Xarelto vs. Eliquis Comparison (GoodRx)