Save time and get answers to complex questions with AI chat
Somatuline generic name?Quartette side effects?When is the expected fda decision date for apotex's ruxolitinib resubmission?When is xarelto's patent set to expire roughly?When will there be a generic loreev available?
See the DrugPatentWatch profile for methotrexate
What other drugs does methotrexate interact with most strongly? Methotrexate levels in the body rise sharply when taken with certain painkillers and antibiotics. NSAIDs such as ibuprofen, naproxen, and aspirin displace methotrexate from binding sites and slow its elimination through the kidneys. Antibiotics including trimethoprim-sulfamethoxazole, penicillins, and tetracyclines inhibit methotrexate's renal excretion, raising toxicity risk. How do these interactions affect patients taking methotrexate? Elevated methotrexate leads to bone-marrow suppression, liver damage, and gastrointestinal toxicity. Patients who need these companion drugs must have frequent blood tests or receive folinic acid rescue. Many physicians substitute acetaminophen for NSAIDs or avoid trimethoprim altogether unless monitoring is tight. Why are companies challenging this patent? No.
Other Questions About Methotrexate :