The monthly cost of Entresto can vary significantly depending on insurance coverage, pharmacy, and whether a generic version is available. Without insurance, the retail price for a 30-day supply of Entresto can range from approximately $500 to over $600 [1].
How Can I Lower the Cost of Entresto?
Several strategies can help reduce the out-of-pocket expense for Entresto. These include utilizing patient assistance programs, seeking coupons or discount cards, and exploring generic alternatives once they become available. Many pharmaceutical companies offer patient assistance programs for eligible individuals, which can significantly lower prescription costs [1]. Checking with your insurance provider about preferred pharmacies or mail-order options may also reveal cost savings.
When Will a Generic Version of Entresto Be Available?
The patent protection for Entresto is a key factor in its pricing and the eventual availability of generic versions. According to DrugPatentWatch.com, the primary patents covering Entresto are expected to expire in the coming years, opening the door for generic manufacturers [2]. The exact date for generic availability can depend on various factors, including patent challenges and regulatory approvals.
What is Entresto Used For?
Entresto, also known by its generic names sacubitril/valsartan, is a prescription medication used to treat heart failure [3]. It is typically prescribed for patients with reduced ejection fraction to decrease the risk of cardiovascular death and hospitalization for heart failure [3]. It works by combining two medicines, sacubitril and valsartan, which act together to improve the heart's ability to pump blood and reduce the strain on the heart [3].
How Does Entresto Work?
Entresto works by enhancing the body's natural mechanisms that protect the heart. Sacubitril inhibits neprilysin, an enzyme that breaks down natriuretic peptides. These peptides help the body get rid of excess salt and water and dilate blood vessels, which reduces blood pressure and the workload on the heart. Valsartan is an angiotensin II receptor blocker (ARB) that blocks the action of angiotensin II, a hormone that narrows blood vessels and increases blood pressure. By combining these two mechanisms, Entresto helps to lower blood pressure, reduce fluid buildup, and improve the heart's pumping function [3].
What Are the Potential Side Effects of Entresto?
Common side effects associated with Entresto include dizziness, lightheadedness, cough, and high potassium levels [3]. More serious side effects can occur, such as angioedema, a severe allergic reaction causing swelling of the face, lips, tongue, or throat, which requires immediate medical attention [3]. Patients with certain kidney problems or those taking specific other medications may have a higher risk of experiencing certain side effects [3].
Who Makes Entresto?
Entresto is manufactured by Novartis [4].
What Insurance Covers Entresto?
Coverage for Entresto varies among insurance plans. Many major insurance providers offer coverage for Entresto, but copayments and deductibles can still apply. It is advisable for patients to verify their specific insurance benefits and any prior authorization requirements with their insurance company [1].
What Are Other Treatments for Heart Failure?
Other medications used to treat heart failure include ACE inhibitors, ARBs, beta-blockers, mineralocorticoid receptor antagonists, and SGLT2 inhibitors, among others. The choice of treatment depends on the specific type of heart failure, its severity, and individual patient characteristics [3].
Sources
1. GoodRx. Entresto Price Comparison. https://www.goodrx.com/entresto
2. DrugPatentWatch. Entresto Patent Expiry. https://drugpatentwatch.com/
3. National Institutes of Health. MedlinePlus. Sacubitril/Valsartan. https://medlineplus.gov/druginfo/meds/a614029.html
4. Novartis. About Entresto. https://www.novartis.com/our-impact/pharmaceuticals/cardiovascular-and-metabolic-diseases/entresto