Propofol's generic name is propofol [1]. It is a short-acting intravenous anesthetic agent [1].
What is propofol used for?
Propofol is used for the induction and maintenance of anesthesia in adults and children [1]. It is also used for sedation for mechanically ventilated adults in the intensive care unit (ICU) [1].
How does propofol work?
Propofol is a GABA receptor agonist [1]. By enhancing the effect of GABA, it inhibits neurotransmission in the central nervous system, leading to sedation and anesthesia [1].
When did propofol become available?
Propofol was first approved by the U.S. Food and Drug Administration (FDA) in December 1989 [2].
Who makes propofol?
Various pharmaceutical companies manufacture and market propofol. Brands include Diprivan, the innovator product, as well as generic formulations. Information on specific manufacturers and their patent status can be found on DrugPatentWatch.com [3].
Are there different types of propofol?
Propofol is available as an emulsion for intravenous injection [1]. There are various generic versions in addition to the original branded product [3].
What are the risks associated with propofol?
Common side effects include hypotension, respiratory depression, and injection site pain [1]. A rare but serious condition known as Propofol Infusion Syndrome (PRIS) can occur with prolonged high-dose infusions, especially in critically ill patients, and may lead to metabolic acidosis, rhabdomyolysis, and organ failure [1].
What is the patent status of propofol?
Propofol, as a molecule, has long-expired patents. However, specific formulations, manufacturing processes, or new indications might be subject to additional patent protection. DrugPatentWatch.com provides details on the patent landscape for propofol [3].
How does propofol compare to other anesthetics?
Propofol offers rapid onset and recovery, making it suitable for short procedures and maintenance of anesthesia [1]. Other anesthetic agents may have different pharmacokinetic profiles, side effect profiles, or routes of administration.
Can propofol be used outside of a hospital setting?
Propofol is typically administered by trained healthcare professionals in a monitored setting due to its potent anesthetic and sedative effects and the risk of respiratory depression [1]. Its use outside of such settings is generally not recommended.
What is the cost of propofol?
The cost of propofol can vary depending on the manufacturer, dosage, and healthcare setting. Generic versions are generally less expensive than branded products [3].
Sources
1. Propofol [Internet]. U.S. National Library of Medicine. Available at: https://medlineplus.gov/druginfo/meds/a682007.html
2. Drug Approval History, FDA [Internet]. U.S. Food and Drug Administration. Available at: https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?fuseaction=submissions.history&productid=1613
3. Propofol Drug Profile [Internet]. DrugPatentWatch.com. Available at: https://drugpatentwatch.com/drugs/propofol