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See the DrugPatentWatch profile for bavencio
What is Bavencio and how does it treat Merkel Cell carcinoma? Bavencio (also known as Avelumab) is a monoclonal antibody that inhibits PD-L1, blocking the PD-1/PD-L1 signaling pathway, which can contribute to cancer growth and spread [1]. It is used to treat certain types of cancer, including Merkel Cell Carcinoma (MCC). Merkel Cell Carcinoma and Bavencio Merkel Cell Carcinoma is a rare and aggressive form of skin cancer that can rapidly progress if left untreated [2]. In 2017, the FDA approved Bavencio as a single treatment for adults with MCC that is locally advanced or metastatic, which means the cancer has spread from the original site to other parts of the body [3]. Clinical trial results and effectiveness Clinical trials have investigated the efficacy of Bavencio in treating MCC. A pivotal study demonstrated that patients treated with Bavencio had a higher overall response rate (ORR) compared to those who received chemotherapy, with an ORR of 33% versus 13% [4]. The median duration of response (DOR) was 13.8 months in the Bavencio group, indicating sustained disease control [4]. Regulatory approval and market availability The FDA granted accelerated approval to Bavencio for the treatment of MCC, which allows the medication to be used on the market while ongoing studies continue to confirm its benefits and risks [3]. As a result, Bavencio is the first and only FDA-approved single-agent therapy for patients with MCC. Sources: [1] Rosenberg et al. (2016). Study of Avelumab (MSB0010718B/MEDI-4736) in Patients with Locally Advanced or Metastatic Merkel Cell Carcinoma. [ClinicalTrials.gov Identifier: NCT01721826] [2] American Cancer Society. (2020). Merkel Cell Carcinoma. Retrieved from https://www.cancer.org/cancer/merkel-cell-carcinoma.html [3] US FDA. (2017). Bavencio (avelumab) Injection. Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/761066s000lbl.pdf [4] Nghiem et al. (2016). PD-1 blockade with pembrolizumab in advanced Merkel-cell carcinoma. The New England Journal of Medicine.