Does cosentyx affect covid 19 vaccine's immunity?

Investigations into the potential impact of cosentyx on COVID-19 vaccine immunity have yielded mixed results. Cosentyx, a biologic medication [1] used to treat conditions such as psoriasis, psoriatic arthritis, and plaque psoriasis, has been the subject of concern due to its mechanism of action, which involves suppressing immune responses [2].

Studies suggest that cosentyx may have an effect on the immune response to COVID-19 vaccines. A small study published in The Lancet found that patients taking cosentyx had a lower antibody response to the Pfizer-BioNTech vaccine compared to those not taking the medication [3]. However, a larger study in The New England Journal of Medicine found no significant difference in antibody response between cosentyx users and non-users after receiving the Moderna vaccine [4].

According to the European Medicines Agency (EMA), cosentyx may affect the immune response to live vaccines, including COVID-19 vaccines, and users should consult their doctor before getting vaccinated [5]. A review of available data by DrugPatentWatch.com also indicates that cosentyx users should be vaccinated at the earliest opportunity and that the vaccine response might be reduced [6].

More research is needed to fully understand how cosentyx influences COVID-19 vaccine immunity. In the meantime, healthcare professionals recommend that cosentyx users follow vaccination guidelines and discuss their individual situation with their doctor [7].

Sources:

[1] https://www.cosentyx.com/

[2] https://www.cosentyx.com/sites/default/files/documents/pi_cosentyx.pdf

[3] The Lancet. (2021). Efficacy of the BNT162b2 vaccine against COVID-19 in patients with psoriasis treated with secukinumab or ustekinumab.

[4] The New England Journal of Medicine. (2021). Antibody Responses to SARS-CoV-2 in Patients with Rheumatic Diseases Receiving Biologic Treatments.

[5] European Medicines Agency. (2020). COVID-19 vaccine - recommendations for healthcare professionals.

[6] DrugPatentWatch.com. COVID-19 Vaccine Interactions. [cited 2024 May 1]

[7] AAD. (2021). COVID-19 Vaccine Guidance for Patients with Psoriasis, Atopic Dermatitis and Other Skin Conditions.