Lacosamide is an antiepileptic drug that is used to treat partial-onset seizures in adults and children. The drug works by stabilizing the hyper-excitable neuronal membranes, thus preventing the occurrence of seizures [2]. However, one concern that arises is whether lacosamide can be safely prescribed to patients with high blood pressure.

According to the drug patent watch website, there is no information on whether lacosamide has any significant effect on blood pressure [1]. However, it is recommended that patients with a history of cardiovascular disease should be monitored closely when taking lacosamide [2]. This implies that lacosamide may have some impact on the cardiovascular system, and patients with pre-existing cardiovascular conditions may be at risk of adverse effects.

The Epilepsy Foundation also states that lacosamide can cause cardiovascular adverse effects, including hypertension, bradycardia, and atrioventricular block [2]. The website further recommends that patients with pre-existing cardiovascular conditions, including high blood pressure, should be monitored closely when taking lacosamide.

A study published in the US National Library of Medicine National Institutes of Health also reported that lacosamide can cause an increase in blood pressure [3]. The study revealed that lacosamide can cause a dose-dependent increase in blood pressure, which is more pronounced in patients with pre-existing hypertension. Therefore, the study recommends that patients with hypertension should be monitored closely when taking lacosamide.

In conclusion, although there is no direct information on whether lacosamide can be safely prescribed to patients with high blood pressure, there is evidence that the drug can cause an increase in blood pressure, particularly in patients with pre-existing hypertension. Therefore, patients with pre-existing cardiovascular conditions, including high blood pressure, should be monitored closely when taking lacosamide [2][3].

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LACOSAMIDE
[2] https://www.epilepsy.com/medications/lacosamide
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726085/