Based on the information provided, I found one source that discusses changes in plasma amino acids with Lipitor (atorvastatin) treatment. However, the source does not provide a definitive conclusion on this matter.

In a study published in the Journal of Clinical Lipidology, researchers investigated the impact of atorvastatin therapy on plasma amino acids in patients with hyperlipidemia [1]. The study found that atorvastatin treatment led to significant changes in several plasma amino acids, including an increase in asparagine, glutamine, and histidine, and a decrease in alanine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tyrosine, and valine. However, the study did not explicitly state whether these changes were clinically significant or not.

It is important to note that the study had a small sample size (n=20), and further research is needed to confirm these findings and determine their clinical relevance.

In summary, based on the available information, there is some evidence to suggest that atorvastatin therapy may lead to changes in plasma amino acids. However, more research is needed to determine the clinical significance of these changes.

Sources:

1. <https://www.drugpatentwatch.com/news/atorvastatin-treatment-leads-to-changes-in-plasma-amino-acids-in-patients-with-hyperlipidemia/>