See the DrugPatentWatch profile for Nifedipine
Nifedipine's earliest patent was granted in 1966. [1] The initial patent filing date for nifedipine was November 20, 1965, and it was granted as U.S. Patent 3,485,827 on December 23, 1969. [2]
When does nifedipine patent exclusivity end?
The original patent for nifedipine, filed in 1965, would have expired long ago. [1, 2] However, pharmaceutical companies often seek additional patents for new formulations, methods of use, or delivery systems of existing drugs. These secondary patents can extend market exclusivity beyond the life of the original composition of matter patent. [3] Information on specific secondary patents and their expiry dates for nifedipine would require a detailed patent search. DrugPatentWatch.com is a resource for tracking drug patents and exclusivity periods. [4]
How is nifedipine used to treat medical conditions?
Nifedipine is a calcium channel blocker. It works by relaxing blood vessels, which lowers blood pressure and reduces the workload on the heart. [5] This action makes it effective in treating:
* Hypertension (High Blood Pressure): By dilating blood vessels, nifedipine allows blood to flow more easily, thus reducing pressure. [5]
* Angina Pectoris: This condition involves chest pain caused by insufficient blood flow to the heart muscle. Nifedipine improves blood flow to the heart, reducing the frequency and severity of angina attacks. [5]
Are there different types or formulations of nifedipine?
Yes, nifedipine is available in various formulations, including immediate-release and extended-release (ER) versions. [6] Extended-release formulations are designed to release the medication gradually over a longer period, allowing for less frequent dosing and potentially a more stable blood concentration. [6]
What are the common side effects of nifedipine?
Common side effects associated with nifedipine use can include headache, dizziness, flushing, peripheral edema (swelling in the ankles or feet), and fatigue. [7] It is important for patients to discuss any potential side effects with their healthcare provider.
Can generic versions of nifedipine be made?
Once nifedipine's primary patents expired, generic versions became available. [3] Generic medications contain the same active ingredient as their brand-name counterparts and are proven to be bioequivalent. [8] The availability of generics generally leads to lower medication costs.
What is the difference between nifedipine and other calcium channel blockers?
Nifedipine belongs to the dihydropyridine class of calcium channel blockers. Other classes, such as non-dihydropyridines (e.g., verapamil, diltiazem), work on both the heart and blood vessels. Dihydropyridines like nifedipine primarily target blood vessels, causing more pronounced vasodilation. [5]
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Sources:
[1] https://patents.google.com/patent/US3485827A/
[2] https://patents.google.com/patent/US3485827A/
[3] https://www.drugpatentwatch.com/
[4] https://www.drugpatentwatch.com/
[5] https://www.ncbi.nlm.nih.gov/books/NBK542213/
[6] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3911104/
[7] https://www.nhs.uk/medicines/nifedipine/
[8] https://www.fda.gov/drugs/generic-drugs/what-generic-drugs