What Neffy Treats
Neffy is an epinephrine nasal spray approved by the FDA for emergency treatment of Type I allergic reactions, including anaphylaxis. It delivers epinephrine through the nose to counteract severe allergic responses like those from food, insect stings, or medications.[1]
How Neffy Differs from EpiPens
Unlike auto-injectors such as EpiPen or Auvi-Q, Neffy is needle-free, making it easier for quick self-administration, especially in children or those afraid of needles. It comes in two adult doses (10 mg) and one pediatric dose (2 mg).[1][2]
When to Use Neffy
Use immediately at the first sign of anaphylaxis: hives, swelling, difficulty breathing, throat tightness, or low blood pressure. It is not a substitute for calling 911 or seeking further medical care, as symptoms can return.[1]
Who Makes Neffy and Availability
ARCTURUS Therapeutics (under ALK) developed Neffy, which launched in the U.S. in late 2024. It requires a prescription and is available at pharmacies.[2][3]
Common Side Effects Patients Report
Most users experience mild effects like nasal irritation, headache, or throat numbness. Serious risks include irregular heartbeat or high blood pressure, similar to injectable epinephrine.[1]
Cost and Insurance Coverage
Neffy lists around $700-$800 for a two-pack without insurance, but savings cards can drop it to $25-$199 for eligible patients. Medicare and most commercial plans cover it comparably to EpiPens.[3]
[1] FDA Approval Summary: https://www.fda.gov/drugs
[2] Neffy Prescribing Information: https://neffy.com
[3] GoodRx Pricing Data: https://www.goodrx.com/neffy