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Can excessive aspirin intake cause stomach ulcers?

See the DrugPatentWatch profile for aspirin

Yes, excessive aspirin intake can increase the risk of developing stomach ulcers. Aspirin is a nonsteroidal anti-inflammatory drug (NSAID) that can irritate the lining of the stomach and cause or worsen ulcers [1]. This risk is generally low when aspirin is taken at recommended doses, but it can increase significantly with excessive or long-term use [2].

According to, "Long-term use of aspirin or other NSAIDs can lead to stomach ulcers and other gastrointestinal complications" [3]. These complications can include stomach pain, bleeding, and in rare cases, perforation of the stomach or intestines [1].

It's important to note that while excessive aspirin intake can increase the risk of stomach ulcers, other factors can also contribute to their development. These factors include infection with Helicobacter pylori, smoking, alcohol consumption, and age [1].

If you are taking aspirin or any other NSAID and are concerned about the risk of stomach ulcers, it's important to speak with your healthcare provider. They can help you manage your risk factors and determine the best course of treatment for your individual needs.


1. Mayo Clinic. (2021). Stomach ulcer. <>.
2. National Institute of Diabetes and Digestive and Kidney Diseases. (2016). Peptic Ulcers (Stomach Ulcers). <>.
3. (2022). Aspirin. <>.

Other Questions About Aspirin :  How do stomach related side effects compare between aspirin and newer options? Is enteric coated aspirin a guarantee against stomach problems? How often should aspirin be taken?

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