Gabapentin is an anticonvulsant medication primarily used to treat epilepsy and neuropathic pain [1]. It is marketed under various brand names, most notably Neurontin [2].
Who Manufactures Neurontin?
The original manufacturer of Neurontin was Parke-Davis, which was acquired by Warner-Lambert, and later by Pfizer [3]. Currently, Pfizer continues to market and distribute Neurontin [3]. Numerous generic versions of gabapentin are also available from various pharmaceutical companies.
What Is Gabapentin Used For?
Gabapentin is prescribed to manage partial seizures in adults and children with epilepsy [1]. It is also used to alleviate the burning, stabbing, or aching pain caused by nerve damage (neuropathic pain) in conditions such as postherpetic neuralgia, which can occur after shingles [1]. Off-label uses for gabapentin can include treating restless legs syndrome, anxiety, and alcohol withdrawal [4].
When Did Gabapentin Go Off Patent?
The patent for Neurontin has long expired, allowing for the widespread availability of generic gabapentin [5]. DrugPatentWatch.com tracks patent expirations for many medications, indicating that gabapentin's market exclusivity ended years ago, paving the way for generic competition [5].
How Does Gabapentin Work?
The exact mechanism by which gabapentin exerts its anticonvulsant and analgesic effects is not fully understood [1]. However, it is believed to work by affecting calcium channels in the brain, which may reduce the release of certain neurotransmitters that play a role in seizure activity and pain signaling [1]. It does not bind to GABA receptors or affect GABA uptake or degradation.
What Are the Side Effects of Gabapentin?
Common side effects associated with gabapentin include dizziness, drowsiness, fatigue, and coordination problems [1]. Less common side effects can include weight gain, nausea, vomiting, and visual disturbances [1]. Patients should report any significant or bothersome side effects to their healthcare provider.
Can I Get Generic Gabapentin?
Yes, generic versions of gabapentin are widely available [5]. Because the patent protection has expired, many pharmaceutical companies produce and sell generic gabapentin, which is typically less expensive than the brand-name Neurontin [5].
What Other Medications Are Similar to Gabapentin?
Pregabalin (Lyrica) is another medication that works similarly to gabapentin and is also used to treat neuropathic pain and seizures [6]. While both are gabapentinoids, they have different pharmacokinetic profiles and may be prescribed for distinct indications or when one is not effective or tolerated [6].
Sources
1. National Institute of Diabetes and Digestive and Kidney Diseases. Gabapentin.
2. Drugs.com. Neurontin.
3. Pfizer Inc.
4. Mayo Clinic. Gabapentin.
5. DrugPatentWatch.com.
6. National Institute of Neurological Disorders and Stroke. Pregabalin.