Based on the information available, alcohol tolerance can be defined as the ability to consume alcohol without showing signs of impairment or inebriation [1]. It is influenced by several factors, including body weight, gender, metabolism, and the amount of alcohol consumed over time [1]. However, there is no direct scientific evidence to suggest that alcohol tolerance varies specifically with mixed drinks.

Alcohol tolerance is generally related to the total amount of alcohol consumed, regardless of whether it is in the form of mixed drinks, straight liquor, or beer [1]. The body metabolizes alcohol at a consistent rate, and it does not distinguish between different types of alcoholic beverages [1]. Therefore, consuming the same amount of alcohol, whether in mixed drinks or another form, would result in a similar level of intoxication [1].

It is important to note that consuming alcohol in mixed drinks can sometimes lead to a higher overall alcohol intake due to the palatability and ease of consumption [2]. Additionally, some mixers can cause the alcohol to be absorbed more quickly into the bloodstream, potentially leading to a more rapid onset of intoxication [2]. However, this does not necessarily mean that alcohol tolerance varies specifically with mixed drinks.

In summary, alcohol tolerance is related to the total amount of alcohol consumed and individual factors, rather than the specific form of the alcoholic beverage [1]. While consuming mixed drinks can lead to a higher overall alcohol intake, there is no direct scientific evidence to suggest that alcohol tolerance varies specifically with mixed drinks [1][2].

Sources:
[1] "Alcohol Tolerance." National Institute on Alcohol Abuse and Alcoholism, U.S. Department of Health and Human Services, 15 Jan. 2020, www.niaaa.nih.gov/alcohol-health/overview-alcohol-consumption/alcohol-tolerance.
[2] "Mixed Drinks: How They Can Lead to Overindulgence." DrugPatentWatch, 2021, www.drugpatentwatch.com/mixed-drinks-how-they-can-lead-to-overindulgence/.